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KMID : 1001020110090010082
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Journal of Urologic Oncology
2011 Volume.9 No. 1 p.82 ~ p.87
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Management and Long-term Outcome of Testicular Germ Cell Tumor
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Park Seo-Yong
Lin Soo-Hyun
Lee Geon-Seok
Seo Seong-Il
Jeon Se-Hyun
Lee Hyun-Moo
Choi Han-Yong
Jeong Byong-Chang
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Abstract
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Purpose: To present the therapeutic strategies and long-term follow-up results of testicular germ cell tumors (GCT) based on an 11-year single center experience.
Materials and Methods: The medical records of testis cancer cases diagnosed between January 1996 and November 2006 were reviewed. Patient demographics, cancer histopathology and stage, adjuvant therapy, survival data are reviewed and analyzed.
Results: A total of 51 testicular GCT, including seminoma in 31, and non-seminomatous GCT (NSGCT) in 20 were enrolled in the present study. Mean patient age at diagnosis was 35.6 years (range 18-69), with a median follow-up of 53 months (range 5-163). There were no cases with bilateral testicular GCT in this study cohort. Among 51patients, 30 (58.8%) were stage I, 10 (19.6%) were stage IIA/IIB, and 11 (21.6%) were IIC/III. Of the 30 patients with stage I testicular GCT, two patients who had been under surveillance showed relapse at retroperitoneal lymph nodes, and both patients cured with salvage chemotherapy. Meanwhile, there was no recurrence in 14 patients who received adjuvant chemo or radiotherapy after radical orchiectomy. The overall 5-year cancer specific survival was 95.9%.
Conslusions: Our long-term follow-up results confirm the excellent prognosis for patients with testicular GCT, and indicate that surveillance does not compromise survival. In stage I testicular germ cell tumor, active surveillance could minimize treatment-related morbidity. Before deciding surveillance, however, psychological impacts on patients, economic and social costs in addition to patients’ compliance should also be considered.
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KEYWORD
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Testicular neoplasm, Neoplasm staging, Survival
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